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Department of Interventional Radiology, Dotter Interventional Institute, Oregon Health and Science University, Portland, OR, USA; Department of Radiation Oncology, Oregon Health and Science University, Portland, OR, USA; Division of Hematology and Medical Oncology, Department of Internal Medicine, Oregon Health and Science University, Portland, OR, USA; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Oregon Health and Science University, Portland, OR, USA Correspondence to: Khashayar Farsad. Dotter Department of Interventional Radiology, 3181 SW Sam Jackson Park Road, L-605, Portland, OR 97239, USA. Email: farsad@ohsu.edu. Comment on: Kim BK, Kim DY, Byun HK, et al. Efficacy and Safety of Liver-Directed Concurrent Chemoradiotherapy and Sequential Sorafenib for Advanced Hepatocellular Carcinoma: A Prospective Phase 2 Trial. Int J Radiat Oncol Biol Phys 2020;107:106-15.

Combined locoregional and systemic therapy for advanced hepatocellular carcinoma: finally, the future is obscure