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Uterine prolapse as a common form of pelvic organ prolapse (POP) is very rare during pregnancy. The literature was extremely limited concerning the management and causation of uterine prolapse during pregnancy women, especially in nulliparous women. We reported two cases of uterine prolapse in two primigravid female. Analysis and recommendations regarding the reasons and management of this condition was provided with past 20-year literature review. In our report, two patients noticed a lump protruding from vagina in the third and second trimester of pregnancy and were found uterine prolapse (28+3 weeks and 24 weeks of gestation respectively). One patient' prolapsed uterus cannot be returned spontaneously, vaginal packing with sterilized oil gauze and indwelling catheter were executed. She was hospitalized and with careful antenatal care. Corticosteroids were administered for fetal lung maturation. But the patient underwent emergency cesarean section because of obstetric factors two days later and two healthy twins were born. Another one treated with conservative antenatal management for a month, and with cesarean delivery at 33+6 weeks of pregnancy. After the delivery, patients were found no uterine prolapse at one-month post-partum examination. Successful pregnancy outcome of uterine prolapse depending on symptomatology, severity of the prolapse, obstructed status and the preference of patients; based on these facts require individualized management and treatment.

Successful deliveries of uterine prolapse in two primigravid women after obstetric management and perinatal care: case reports and literature review