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Diffuse large B-cell lymphoma (DLBCL), comprise the most commonly diagnosed non-Hodgkin lymphoma. Approximately 60–65% of patients can be cured with standard front-line therapy R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). However, the progress in the understanding of the disease has led us to appreciate its underlying heterogeneity.

Better understanding and new challenges in high grade lymphomas