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Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy; Division of Thoracic Surgery, Maria Cecilia Hospital, GVM Care & Research Group, Via Corriera 1, 48033 Cotignola (RA), Italy; AUSL Area Vasta Romagna, Viale V. Randi, 5, 48121 Ravenna, Italy; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy; Department of Surgical and Diagnostic Sciences (DISC), University of Genova and IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy Contributions: (I) Conception and design: S Mattioli; (II) Administrative support: M Lugaresi; (III) Provision of study materials or patients: V Pilotti, L Ferruzzi; (IV) Collection and assembly of data: A D’Errico, R Fiocca, D Malvi, G Raulli, B Mattioli, N Daddi; (V) Data analysis and interpretation: M Lugaresi; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Prof. Sandro Mattioli. Department of Medical and Surgical Sciences (DIMEC) Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. Email: sandro.mattioli@unibo.it.

Total gastrectomy versus upper pole gastrectomy for the surgical therapy of Siewert type II adenocarcinoma of the esophagus: pathology may drive the choice