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Obesity is defined as a body mass index (BMI) of ≥ 30 kg/m [1]. In Korea, obesity is defined as BMI of 25 kg/m based on the WHO AsiaPacific perspective for Asians [2,3]. The prevalence of obesity defined by BMI >25 kg/m was increased from 36.2% in 2011 to 38.9% in 2016. The prevalence rate of obesity has also been > 60% in America from 2012 [4]. Obesity needs to be considered as chronic disease [5]. It was relevant to cardiovascular diseases [6], and a report showed that approximately 40% of the mortality rate in the U.S. was due to obesity or obesity-related diseases in 2000 [7]. To reduce body weight, a weight control program that includes a dietary therapy and exercise therapy needs to be tried [8], and an appetite suppressant has been generally prescribed for obesity care [9]. Phentermine, one of the popular appetite suppressants, was approved Meta-analysis of Change in Weight and Heart Rate for Phentermine in Obesity Yeonju Woo, Hyomi Jeong Researcher, Institute of Korean Medical Science, Pusan National University, Yangsan; Manager, LSK Global Pharma Services, Seoul, Korea