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Aim. Kidney functional state and chronic kidney disease development have been assessed in middle age patients with arterial hypertension without associated diseases. Material and methods. 58 patients with essential hypertension aged from 38 to 60 years were examined. Diagnostic examination in the hospital was suffi cient and included physical examination and history taking, complete blood count and biochemistry, common urine analysis, glomerular fi ltration rate calculation, functional diagnostic examination, monitoring of clinical state and test results during inpatient stay, after 3 and 6 months. The patients with associated cardiovascular disorders or serious inner organ diseases have not been enrolled to the study. Results and discussion. Smoking, obesity, dyslipidemia and arterial hypertension are the main factors that infl uence renal dysfunction development, manifested by hyposthenuria, albuminuria and proteinuria, in patients with essential hypertension without associated cardiovascular diseases. Hypertensive nephropathy and chronic kidney disease were diagnosed in 67% of cases with duration of arterial hypertension of more than 10 years. Conclusion. The results of the study confi rm that smoking, obesity, dyslipidemia and arterial hypertension infl uence renal dysfunction development, manifested by albuminuria/proteinuria. The risk of hypertensive nephropathy development is 13 times higher in duration of essential hypertension of more than 10 years comparing to the duration of less than 5 years (RR=13,3, CI 95% 1,92–92,61; p<0,001). Antihypertensive nephroprotective therapy contributes to regression of albuminuria.

CLINICAL AND FUNCTIONAL STATE OF KIDNEYS IN MIDDLE AGE PATIENTS WITH ARTERIAL HYPERTENSION