English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Aim. To study the changes in the axis of the «growth hormone (GH) — insulin-like growth factor-1 (IGF-1)» and the insulin sensitivity of tissues in children born with IUGR, depending on the mass-height dynamics. Material and methods. 49 children born with IUGR and 30 control children born without IUGR were prospectively examined. Levels of GH and IGF-1 levels were determined in cord blood and estimation of the insulin sensitivity of tissues was carried out using the homeostatic model (HOMA-IR) at the age of 3 months. Results and discussion. Demanstrated that IGF-1 levels in cord blood in children with IUGR in comparison with the control group was significantly lower, 52,20 (11,61—99,40) and 103,50 (46,17—181,99) ng/ml, respectively (p <0,05). There were no significant differences of growth hormone level in the umbilical cord blood between the groups. There were no significant differences of the level of IGF-1 and GH at the age of 3 months between the study and control groups. The values of basal insulin resistance of tissues (HOMA- IR) were significantly higher in children of study group: 1,12 (0,36—3,99) and 0,88 (0,21—1,64) ng/ml respectively (p<0,05). 16 of 23 children born with IUGR (69,5%) had «growth leap» in the first 3 months of life assessed by weight, and/or an increase of 2 or more centile corridor (CC). Accelerating the pace of growth was associated with significantly higher levels of IGF-1 and GH levels in 3 months of life. Conclusion. Revealed features of «GH-IGF-1» axis and insulin sensitivity of tissues in children with IUGR aimed to stimulation of postnatal growth and can predispose the development of carbohydrate metabolism disorders in later life.

chanGes in « insulin-like Growth factor-1—Growth hormone» axis and insulin sensitiVity in children with intrautherine Growth retardation