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The present article is devoted to the analysis of perinatal anamnesis and genes of the main histological compatibility complex in bronchopulmonary dysplasia (BPD) development in premature infants with very low body weight at birth (n=108) in comparison with premature infants of like gestational age, but without BPD development (n=367). The most significant maternal (вronchial asthma, alcoholism, tobacco smoking, horioamnionitis) and neonatal (APV more than 6 days, therapy with high concentration of oxygen, extensive hemorrhages in a brain, an open arterial channel, a male of the baby) risk factors for BPD development as well as positive association with certain groups of A, B, DRB1 alleles of HLA-region loci have been determined in infants with gestational age less than 32 weeks. This confirms the possibility of the main histological compatibility complex genes impact on BPD development.

vestnik sovremennoj kliničeskoj mediciny

The characTerisTic of genes of The main hisT ological compa TibiliTy complex and peryna Tal anamnesis aT prema Ture infanTs wiTh bronchopulmonary dysplasia