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Purpose: assessment of NT-proBNP diagnostic importance in CHF patients of ischemic genesis. Methods: 69 CHF patients were included in the study. Inclusion criteria were CHF symptoms developed after Q-wave myocardial infarction and shown in ECG findings, and informed consent of the patients. NT-proBNP level was defined by enzyme immunoassay. Statistical processing of the data obtained was performed using software package STATISTICA 7,0. Results were considered statistically significant at p<0,05. Numerical data is presented in the form of Ме [10-90%] (mediana, 10-90 per cent). Results: NT-proBNP level in the study group was 120,0 [60; 470] pg/ml. Correlation analysis of NT-proBNP level and the studied clinical indices was carried out. Positive significant relation (р<0,05) was noted between NT-proBNP and the patients’ age (r=0,35), body mass index (BMI) (r=0,38), heart rate (HR) (r=0,50), CHF functional class (r=0,46), C-reactive protein (CRP) (r=0,55), left atrial end-systolic dimension (LAESD) (r=0,53), left ventricular end-systolic dimension (LVESD) (r=0,41), left ventricular end-diastolic dimension (LVEDD) (r=0,40), left ventricular end-systolic volume (LVESV) (r=0,39), left ventricular end-diastolic volume (LVEDV) (r=0,38), systolic pulmonary artery pressure (sPAP) (r=0,62), left ventricular myocardial mass index (LVMMI) (r=0,58). Negative significant relation (р<0,05) was noted between NT-proBNP and left ventricular ejection fraction (LVEF) (r=-0,54). According to mediana level the patients were divided into two groups: group I enrolled patients with NT-proBNP ≤ 120, pg/ml (35 patients), group II enrolled patients with NT-proBNP>120,0 pg/ml (34 patients). Patients in group II were significantly older (р=0,04), had a history of old myocardial infarctions (р=0,01), longer period of CF manifestations (р=0,04), more increased HR (р=0,003), higher CRP level (р=0,005). In group II in comparison with the group I the patients had more unfavorable events (р=0,03), CHF progression (р=0,03), recurrent myocardial infarctions (р=0,02), lethal outcomes (р=0,01).

Diagnostic importance of n-terminal fragment of brain natriuretic peptiDe in patients with chronic heart failure of ischemic genesis