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A chronic obstructive pulmonary disease (COPD) is one of the important problems of public health services. However, data on a functional activity of endothelium and influence of anti-inflammatory therapy on endothelial dysfunction at COPD patients are presented insufficiently. The aim of the present study was the determination of influence of antiinflammatory treatment on endothelial function (endothelin-1 level and results of Celermajer manoeuvre) in 90 severe and moderate COPD patients. The system endothelium dysfunction was found in 60% of patients. The degree of endothelial dysfunction was decreased after anti-inflammatory treatment.

vestnik sovremennoj kliničeskoj mediciny

VasoactiVe function of endothelium in patients with copd and opportunities of its medicamental correction N.A. Kоuzоubov A, A.Yu. GichKiN, v .E. PErlEY