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A differential pulse voltammetry (DPV) platform for the sensing of human immunodeficiency virus (HIV) gene was described through the self-assembling of amino-reduced graphene oxide (NH2-rGO) and β-cyclodextrin (β-CD) on the surface of glassy carbon electrode (GCE). It is making use of the single-stranded DNA (ssDNA) with sequence hybridized with HIV gene. The ssDNA was attached on NH2-rGO/β-CD modified GCE (NH2-rGO/β-CD/GCE) surface, then methylene blue (MB) was interacted with ssDNA to general obvious DPV signal. The HIV gene was then initiated to hybridize with ssDNA on NH2-rGO/β-CD/GCE surface, causing a dramatic decrease in DPV response of MB at potential of −0.25 V (vs. Ag/AgCl). Under optimal experimental conditions, response was linear in the 0.05 pM to 1 pM HIV gene concentration range. The electrochemical biosensor displayed an ultrahigh sensitivity with detection limit of 8.7 fM and excellent selectivity. The modified electrode displayed good reproducibility, ultra-high sensitivity, and terrific selectivity. This electrochemical biosensor was successfully used for the determination of HIV gene in human serum samples.

international journal of electrochemical science

Ultrasensitive and Highly Selective Electrochemical Biosensor for HIV Gene Detection Based on Amino-Reduced Graphene Oxide and β-cyclodextrin Modified Glassy Carbon Electrode