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A new europium-acridine-9-carboxylate (Eu(III)-(9-ACA)2(NO3)) was synthesized and characterized. The interaction of calf thymus DNA (ct-DNA) with Eu(III)-(9-ACA)2(NO3) has been investigated using UV-visible and fluorescence spectroscopic and electrochemical techniques including cyclic voltammetry and differential pulse voltammetry (DPV) on the GCE. UV-absorption spectroscopic techniques were employed to investigate the interaction between the Eu(III)-(9-ACA)2(NO3) and ctDNA. Based on electrochemical and spectroscopic data, the mode of binding of Eu(III)-(9ACA)2(NO3) to DNA through intercalation interaction was concluded. The stoichiometric coefficient (n) and apparent binding constant (β) were calculated to be 1.4 and 9.1 x 10 4 M −1 , respectively. The antibtumor activity of the complex against MDA-MB-231 (mammary cancer) and PC-3 (prostate carcinoma) cell lines was evaluated and the results showed promising activities.

Electrochemical and spectroscopic studies on the interaction of europium-(9-acridine carboxylate)2 complex with calf thymus DNA