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This work developed an electrochemical immunosensor to quantitatively detect CA19-9 in human serum, a pancreatic cancer biomarker, where the electrode materials were thionine (TH) and graphene sheets (GS), and horseradish peroxidase (HRP) and ferroferric oxide (Fe3O4) nanoparticles-loaded mesoporous silica nanoparticles (MSNs) served as labels to amplify signals. The electron transfer and immobilization of primary antibody of CA19-9 (Ab1) were enhanced by the as a substrate, the GS and TH hybrid (GS/TH). MSNs were used as a carrier for immobilization of secondary antibody of CA199 (Ab2), Fe3O4, and HRP. The sensitivity of the immunosensor could be enhanced by the synergistic effect between HRP and Fe3O4. The proposed technique is potential to be applied to clinical analysis or be used to detect other tumor markers.

Electrochemical Immunoassay Determination of a Cancer Biomarker (CA19-9) by Horseradish Peroxidase