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A simple and available strategy was developed for one step electrodeposition of graphene-Au (G-Au) nanocomposites which could be used for highly sensitive electrochemical detection of salbutamol. GAu nanocomposites were simultaneously deposited on glassy carbon electrode by one step electrodeposition method. This resulting G-Au nanocomposites modified electrode was characterized by different methods. Compared to graphene or Au nanoparticles (AuNPs) modified electrodes, this GAu nanocomposites modified electrode dramatically promote the electrooxidation of salbutamol on electrode surface and significantly enhance the differential pulse voltammetry (DPV) current response towards salbutamol. In addition, this one step electrodeposition method improved the stability of the modified G-Au nanocomposites layer. This constructed G-Au nanocomposites based electrochemical sensor exhibits high sensitivity and good selectivity for salbutamol, which may introduce by the synergistic effect of G-Au nanocomposites. Under optimized conditions, the constructed salbutamol sensor showed two linear dynamic ranges (0.05-10 μM and 20200 μM). The linear range and sensitivity of the proposed salbutamol electrochemical sensors are better than other reported values. Moreover, this electrochemical sensor has been successfully applied to the determination of salbutamol in salbutamol sulfate injections with satisfied recoveries (95.4 % to 103.1 %) and precision (1.5 % to 4.6 % of RSD).

One Step Electrodeposition of Graphene-Au Nanocomposites for Highly Sensitive Electrochemical Detection of Salbutamol