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This study aimed to evaluate the antibacterial properties of ethyl- p -methoxycinnamate and  p -methoxycinnamate acid from Kaempheria galanga L. Ethyl- p -methoxycinnamate was isolated from the  n -hexane rhizome extract of  Kaempheria galanga L . Separation and purification of this compound was carried out with vacuum liquid chromatography and column chromatography. Hydrolysis of ethyl- p -methoxycinnamic under alkaline conditions obtained  p -methoxycinnamic acid with a good yield of 85 %. The structure of the compounds were charactrized with IR, NMR spectrophotometer ( 1 H-NMR and  13 C-NMR) and mass spectrophotometer. The antibacterial properties of the compounds were evaluated using microdilution methods against  B. cereus  ATCC 11778,  L. monocytogenes  ATCC 7644,  E. coli  ATCC 25922,  S. enterica sv Typhimurium  ATCC 14028, and  E. aerogenes  ATCC 13048. The compounds showed weak antibacterial properties. Only ethyl  p -methoxycinnamate showed the strongest antibacterial activity, especially against  B. cereus  ATCC 11778 bacteria with MIC values of 62.5 mg /mL. The change of the functional groups provided no significant impact on the antibacterial activity.

TRANSFORMATION OF ETHYL-P-METHOXYCINNAMATE TO P –METHOXYCINNAMIC ACID FROM KENCUR (Kaempheria galanga L.) AND THEIR ANTIBACTERIAL ACTIVITY