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: Diabetes mellitus is a chronic condition indicated by the increasing of blood glucose level which is caused by lack ofinsuline as consequence from disturbance in the insuline secretion. This research is aimed to see the influences of ethanol exstract of Gynura procumbens (Lour.)Merr.toward the reducing of blood glucoselevel and to fix pancreatic histophatology. Methods : methodologyused in this research is methodology of experimental using animal testing. Mices devided into 5 groups consists of negative control, positive control, Group of 50 mg/kg BW dose, 150 mg/kg BW, 300 mg/kg BW and 200 mg/kg BW alloxan induced animal intraperitoneally.The Extract is orally given for 7 days.The research data is analyzed using one way ANOVA test and Followed by Duncan test. Result : the result of research showed that giving ethanol extractof Gynura procumbens (Lour.)Merr.with 50 mg/kg BW doses, 150 mg/kg BW, 300 mg/kg BWwas able to reduce the level of blood glucosesighnificantly (P<0.05) and pancreatic histophatology illustrate the perceptual structure of endocrine cubicleswhich homogenous spreading out on Langerhans Island and proportional looked of cytoplasm. Conclusion : this discovery showed that giving ethanol extractof Gynuraprocumbens (Lour.) Merr.in those three doses above was able to reduce the level of blood glucose and recover pancreatic histopathology which has damaged.

international journal of chemtech research

Activity of Ethanol Extract of Gynura procumbens (Lour)Merr. Leaf to Decrease Blood Glocose Level and Recover Pancreatic Histopathology in White Male Mice Induced by Alloxan