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Highly distinctive diversity patterns of operational dysfunction allow for the contrasting biology of autocrine attributes versus the promotional effects of paracrine action of the PDGF ligand/receptor complex. Indeed, the metastatic capabilities of malignant cells contrast with a primary localization of the parent tumor lesion within scopes of a predominant stromal series of activation as exerted by the PDGF/receptor complex. Homologous pairing of the PDGF ligand polypeptides contrasts with the heterologous pairing of the A-B polypeptides of the PDGF ligand in an extensive cross-talk of pathway effects and of receptor-receptor interactivity within the tumor cell membrane. Overall predominance of stromal biologic effects may paradoxically render the parent malignant cells with potent capabilities in metastatic deposition and further spread.

Distinctive PDGF Biology of Autocrine Action Versus Paracrine Effects in Tumor Cell Growth/Proliferation Versus Metastatic Spread