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Objective: To observe the clinical efficacy and side effects of rectally administered prolonged-release oxycodone hydrochloride tablets on cancer pain.Methods: Seventy-six patients with moderate-severe cancer pain admitted to April 2010-April 2016 were randomly chosen and equally divided into an experimental group and control group. All patients were each treated with prolonged-release oxycodone hydrochloride tablets. The experimental group patients were administered rectally and the control group were administered orally. Clinical efficacy and side effects were observed for both groups.Results: There was no statistically significant difference (p > 0.05) in the pain scores of the two groups after administration of prolonged-release oxycodone hydrochloride tablets after 1h, 3h, 1 day, 3 days and 1 week. Gastrointestinal reaction incidence rates for the experimental group was significantly lower than the control group with the difference being statistically significant (p < 0.05).Conclusion: Rectal administration had the same analgesic effects as oral administration, but had fewer side effects and more clinical value.

Cancer Pain Treated With Rectally Administered Prolonged-Release Oxycodone Hydrochloride Tablets