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Oxidative or redox stress arises from the generation of reactive oxygen species (ROS) as a by-product of oxygen utilization. ROS-mediated damage to DNA accumulates over time and leads to irreversible changes in cellular functions and integrity associated with aging phenotypes. Here, we discuss the contribution of ROS-induced DNA damage to aging and the important role of deficiencies in DNA repair pathways that counteract this damage. We elaborate on the relationship of aging with mutagenesis and epigenetics and conclude with promising avenues to prevent aging.

ROS-Induced DNA Damage as an Underlying Cause of Aging