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Thanks to modern medicine and technology, people are living longer than ever before. The number of Americans age 65 and older is expected to grow 81 percent between 2010 and 2030—exponentially faster than any other age demographic. Consider that of all the people in human history who have lived past the age of 65, two-thirds of them are alive today [1]. With age the No. 1 risk-factor for Alzheimer’s [2], the only leading cause of death in America without an effective treatment or cure, these demographic trendlines paint a stark picture. Barring the discovery of a new effective therapy or method of prevention—combined with the requisite structural updates to our healthcare system that must be undertaken if a cure is to do any good—the number of Americans living with Alzheimer’s disease and dementia will continue to increase from 5.8 million today to an estimated 14 million by 2050 [3]. Unchecked, it will become the biggest public health crisis of the 21st century. Steps are being taken to begin to change the course of this demographic trend. Federal funding for Alzheimer’s research through the National Institutes of Health increased to $2.8 billion this year [4]; advances are being made in drug therapies [5] to treat the disease, and emerging science [6] is demonstrating that actions can be taken to delay or prevent onset of the disease. Despite these developments, the nation and the world are not ready for the growing Alzheimer’s crisis. UsAgainstAlzheimer’s, a venture non-profit organization committed to accelerated action to find an effective treatment or prevention for Alzheimer’s disease, looks at the fight against this disease from a broader context. In its work, it seeks to address various stakeholder perspectives— research, government policy, patients, caregivers, providers and government and private sector insurance payers—and how they all need to fit together in an overall strategy to stop Alzheimer’s. Specifically, UsAgainstAlzheimer’s is advocating for the creation of an “optimal system of care” [7]. This ideal system operates under a “dualpath” pursuit of pharmacological and non-pharmacological interventions, and, at the same time, works to prepare existing healthcare infrastructure to properly implement and distribute an effective treatment or means of prevention. For example, it is important to look beyond just drug-based solutions and explore all avenues of treatment or prevention. Emerging evidence Open Access

A Rapidly Aging Population Requires an Optimal System of Care to Stop Alzheimer’s Disease