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Hepatocyte nuclear factor 4α (HNF4A) has been demonstrated to be an oncogene in gastric cancer (GC). However, the roles of different HNF4A isoforms derived from the 2 different promoters (P1 and P2) and the underlying mechanisms remain obscure.

Analysis of the <i>HNF4A</i> isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis