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Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulation. The aim of the present study was to develop an intravenous formulation of HM30181A (HM) to inhibit P-gp in the brain to effectively deliver paclitaxel (PTX) for the treatment of malignant glioma.

cancer biology and medicine

HM30181A, a potent P-glycoprotein inhibitor, potentiates the absorption and &lt;i&gt;in vivo&lt;/i&gt; antitumor efficacy of paclitaxel in an orthotopic brain tumor model