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Archidendron jiringa (Jack) I.C Nielsen) contains a lot of essential oils, saponins, alkaloids, terpenoids, steroids, tannins, glycosides, and flavonoids. Flavonoid is a secondary metabolite compound in a plant as antimicrobial. This study aims to determine the antimicrobial activity of fractions of ethanol 96%, n-hexan, ethyl acetate, and ethanol-water leaves extract and determine levels of favonoids .   A. jiringa leaves extract were tested against  Streptococus mutans ,  Pseudomonas aeruginosa , and  Candida albicans .  The research using agar disc diffusion technique for antimicrobial  activity and colorimetric method to know the total of flavonoid. C hloramphenicol and ketoconazole were used as a reference standard.  The result of this study shows fractions of ethanol 96%,  n-hexane,  ethyl acetate, and  ethanol-water  A. jiringa leaves extract  can inhibit microbial growth of  S. mutans ,  P. aeruginosa , and  C. albicans .Total of flavonoids on the extract respectively are 1.13%, 0.494%, 2.337%, and 0.549%. determined with complementary colorimetry to each leaf extract fraction A. jiringa with aluminum chloride method. Absorption spectrum measurement using a spectrophotometer.  The higher  percent of flavonoids would cause greater    bacteria inhibitory  zone but  only  0.090 for  pearson correlation value. Conclusions ethyl acetate leaves extract most effective inhibit microbial growth from the other fractions.

Effectiveness of Leaves Extract Fractions of Archidendron jiringa (Jack) I.C Nielsen Against Microbes