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Human beings and disease have always gone hand in hand throughout human history. In most of history, man was able to prevail over infections caused by pathogenic and non-pathogenic agents, with losses and results of the evolution of life and peoples, however, some epidemics/pandemics destabilize human homeostasis and, therefore, promote imbalances. This article, based on a narrative review of the literature, provides an overview of some of the greatest global epidemics of the last three centuries, with the main resources and historical histories of each era, the time when it presents and correlates the activity of human behavior in their propagation and development, specified in Cholera, Spanish Flu and COVID-19, and points out some of the many editions that can still be learned.

A DOENÇA EM CADA SÉCULO: A INFLUÊNCIA DO COMPORTAMENTO SOCIAL NAS PRINCIPAIS PANDEMIAS DOS ÚLTIMOS 200 ANOS