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Major depressive disorder is a multifatorial disease that is influenced by both genetic and environmental factors. This work had as objective to set a possible association of the T102C polymorphism of 5-HTR2A gene and major depression disorder; to research some socio-demographic characteristics, family history of psychiatric disorders and some life style of the population investigated. We performed a case-control study in which 84 individuals living in the do Rio Pardo Valley. All individuals were genotyped for the T102C polymorphism. To socio-demographic data, prevailed the female sex and Caucasian for the group control end case but diverged in relation to education. The smoking habit, number of cigarettes smoked, medicine taken and greater contact with pesticides prevailed in the group of patients. Both groups are sedentary and did not differ in the family history of psychiatric disorders. The allelic and genotype frequencies of the groups studied are in Hardy-Weinberg equilibrium and as our results there was no association between the T102C polymorphism of 5-HTR2A gene and major depression. Key-words: major depression, serotonin, T102C polymorphism , serotonin 2A receptor

O polimorfismo do receptor 2A da 5-Hidroxitriptamina (5- HTR2A) e a incidência de doença depressiva no Vale do Rio Pardo