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Objective: Boron shows antioxidant properties with an unknown mechanism. It was aimed to evaluate the antioxidant potentials and genotoxic risk of ammonium tetra borate on human whole blood cultures for the first time in the extent of this study (n=4). Material and Methods: Ammonium tetra borate was administrated at concentrations between 1.25-1280 µg/ml to cultured blood samples. The micronuclei and chromosomal aberration tests were performed to determine genotoxic effect. In addition, total antioxidant capacity and total oxidative stress levels were measured as biochemical parameters. Results: Our results clearly provided that the all tested concentrations of ammonium tetra borate were notmutagenic. Moreover, ammonium tetra borate showed antioxidant activities at low concentrations and the total oxidative stress levels were not changed at all the concentrations of ammonium tetra borate. Conclusion: Our data’s, clearly indicated that ammonium tetra borate is not mutagenic and it has remarkable antioxidant potential in vitro.

Potent antioxidant and genotoxic effects of ammonium tetraborate in vitro