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Various polyphenols and aminophenols were tested for reactivity with deoxyguanosine and DNA in the presence of hydrogen peroxide and ferric ion. Deoxyguanosine was efficiently hydroxylated at the C-8 position by these treatments. In the case of DNA, strand scission was observed in addition to the hydroxylation of guanine residues.

Hydroxylation of deoxy guanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion.