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Epichlorohydrin is an epoxide compound which is widely used in various industrial fields. The mutagenic action of this compound was first demonstrated in fruit flies,3) and it has since been studied by several investigators.1,2,4) The carcinogenic activity of epichlorohydrin was tested in mice,5,6) but the findings were inconclusive. In the present experiment, the carcinogenic activity of epichlorohydrin was tested in rats, and the chemical was found to induce forestomach hyperplasias, papillomas, and carcinomas. Seventy-two, 6-week-old male outbred Wistar rats (Kiwa Animal Farm, Wakayama), weighing approximately 160g each, were used. Epichlorohydrin (Nakarai Chemicals, Ltd., Kyoto) was dissolved in drinking water freshly every day and placed in a bottle covered with black tape to protect it from the light. Four groups of rats were treated: Group 1 received 0ppm (control group); group 2, 375ppm; group 3, 750ppm; and group 4, 1500ppm. However, epichlorohydrin administration had to be stopped intermittently due to the poor condition of rats, as shown in Fig. 1. The rats were housed in wire cages in an air-conditioned room at

Forestomach tumors induced by orally administered epichlorohydrin in male Wistar rats.