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The effect of various carcinogenic and non-carcinogenic substances on the development of urinary bladder tumors in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosoamine was examined histologically. Preor post-treatment with N-nitrosopiperidine, N-nitrosomorpholine, diethylnitrosoamine, or N-2-fluorenylacetamide inhibited the incidence of urinary bladder tumors in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosoamine, but the production of hyperplasias and papillomas in the urinary bladder epithelium was not inhibited by preor post-treatment with several carcinogens. On pretreatment with various hepatotoxic and nephrotoxic substances, 4-chloroacetanilide and 1-naphthyl isothiocyanate were found to inhibit the production of urinary bladder cancer induced by N-butyl-N-(4-hydroxybutyl)nitrosoamine, the latter especially inhibiting not only the development of cancer but also hyperplasia and papilloma of the urinary bladder epithelium in rats induced by this carcinogen. When the two carcinogens, N-butyl-N-(4-hydroxybutyl)nitrosoamine and N-2-fluorenylacetamide, were administered together, their action of inducing urinary bladder cancer was synergistic. Moreover, DL-tryptophan promoted their actions in producing urinary bladder tumors in rats.

Effect of various carcinogenic and non-carcinogenic substances on development of bladder tumors in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosoamine.