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At the present time Nitrogen-Mustard-N-Oxide (NMO) is being widely used. clinically in the treatment of cancer. The trouble is that with continued use, cancer becomes resistant to an anticancer agent. We have studied both clinically and experimentally the problem of NMO resistance, especially with regard to tumor DNA, on which we report here. We cite here as the first clinical case that of a seventeen year old youth with mediastinal tumor. A thoracotomy was done but resection of the tumor was found to be impossible. After the operation, this patient was given 125mg THM and 700mg NMO and we could see by x-ray film that these alkylating agents were most effective. Thereafter, 25mg TEM and 1600mg NMO were added but up to the present time the tumor has been increasing and it is thus proved that.

Studies on resistant of cancer cells to nitrogen-mustard-N-oxide.