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Obesity is a well Known risk factor of metabolic complications and cardiovascular disease. On the other hand, associations between anthropometric measurements and fat distribution and risk factors for cardiovascular disease have been demonstrated in several populations. To study the association of various measures of adiposity including total body adiposity (body mass index (BMI), waist circumference (WC), percentage of body fat (%BF), with leptin and lipid profile. To study the association between leptin and lipid profile. Serum samples collected from 129 individuals, admitted to Tikrit Teaching Hospital in Tikrit city from February 2013 to January 2014. All individuals had hormonal assay of leptin, and lipid profile, glucose. These samples were divided into three groups of according of BMI. Group 1: (Normal Weight females n=45), Group 2: (Over Weight females n=46), Group 3: (Obese females n=38). The statistical analysis (students t-test) exhibited significant (P> 0.0001) elevation for leptin and lipid profile (Cholesterol, Triglyceride, VLDL, LDL) while significant (P> 0.0001) decrease for HDL in over weight and obese groups compared with normal weight groups. The correlation coefficient (r) between Leptin and other parameters calculated with regression plot showed a positive correlation between Leptin with cholesterol, triglyceride, VLDL while a negative correlation with HDL, and paraoxonase in over weight and obese group. Circulating leptin levels appear to be one of the best biological markers of obesity and hyperleptinemia is closely associated with several risk factors related to obesity syndrome. Leptin act as atherosclerotic factors. K ey wo rd s

Relationship between Leptin and Lipid Profile in Obese Females in Tikrit Province