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The recurrence rate after primary resection for hepatocellular carcinoma (HCC) has been reported to be up to 80%. There is no consensus or guideline about the best treatment option for such recurrent HCC (rHCC). It is therefore of paramount importance to select patients for suitable treatment due to the high risk of associated morbidity and mortality. In this paper, we review the literature on treatment for rHCC and propose a strategy based on the best evidence available. Even in rHCC, it is still possible to achieve cure and good survival rates through careful patient selection. Repeat hepatectomy is recognized as a feasible and safe procedure even in cirrhotic patients and should be considered as the best option with curative intent when the patient is fit enough. Greater adoption of minimally-invasive liver surgery could have the potential to increase the number of candidate patients with rHCC for repeat resection in the next few years. Liver transplantation offers longer disease-free survival compared to repeat resection, curing the underlying cirrhosis, but is not widely available due to organ shortage. When surgery is not feasible, locoregional treatments such as radiofrequency ablation and transarterial chemoembolization have an important role for patients who cannot tolerate repeat hepatectomy and are not suitable for transplantation. For advanced cases, systemic therapy could be considered.

hepatoma research

Treatment options for recurrence of hepatocellular carcinoma after surgical resection: review of the literature and current recommendations for management