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Strong evidence reveals important differences between cancers in the proximal vs . distal colon. Animal models of metastatic colon cancer are available but with varying degrees of reproducibility and several important limitations. We explored whether there were regional differences in the location of murine colon cancers and assessed the utility of murine models to explore the biological basis for such differences.

Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression