English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Aim: Breast cancer is typically detected either during a screening examination or after a woman notices a lump. Breast cancers have different phenotypes depending on the presence/absence of an estrogen receptor (ER) and/or an epidermal growth factor (Her-2) receptor. The objective of the present investigation was to investigate growth inhibitory activity of methanol-, ethanol-, and water-extracts from papaya fruit and leaves on MDA-MB-231 (ER/Her-2), MCF-7 (ER/Her-2), SK-BR3 (ER/Her-2) and MDA-MB-361, AU565 (ER/Her-2) breast cancer cells. Methods: The anti-oxidation potential of papaya extracts was determined by assessing their total polyphenol content, total flavonoid content and by assaying their anti-oxidation capacity. The effects on breast cancer cells proliferation were determined using a WST-1 assay. Results: The seeds and leaves contained higher anti-oxidation potential than that of the skin and pulp fractions. Our data indicate that methanoland ethanol-extracts of papaya leaves, skin, pulp, and seeds have no effect on any of the breast cancer cell lines, whereas water-extract of leaves and seeds caused low to modest cytotoxic effects only on ER-negative breast cancer cell lines. Conclusion: Our data suggest that bioactive compound in papaya leaves can be potentially used to develop anti-cancer agents for ER-negative breast cancer.

Anti-oxidation properties of leaves, skin, pulp, and seeds extracts from green papaya and their anti-cancer activities in breast cancer cells