The role of human papillomaviruses in cancer progression

The role of human papillomaviruses in cancer progression Pinar Tulay, Nedime Serakinci Department of Medical Genetics, Faculty of Medicine, Near East University, 999058 Nicosia, Cyprus. Correspondence to: Dr. Nedime Serakinci, Department of Medical Genetics, Faculty of Medicine, Near East University, 999058 Nicosia, Cyprus. E-mail: nedimeserakinci@gmail.com The importance of human papillomavirus (HPV) infection and its role in the progress of cancer have been widely evaluated. The understanding of HPV association with certain cancers, such as cervical cancer, is very well established. A big step forward in the prevention of HPV associated cancers with the use of early detection by screening strategies has also been taken. In the last decade, development of HPV vaccination has reduced the number of cases in HPV infections and infection induced cancers. In this report, we review the HPV pathogenesis and highlight the mechanism of HPV involvement in cancer development.