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This article presents the results of our own research: comprehensive clinical and laboratory examinations, including data of 24-hour Holter monitoring (HM) in 169 patients with chronic glomerulonephritis at the predialysis stage of the disease. According to HM, 60.3% of the patients examined had episodes of supraventricular ectopic beats, and 28.9% — ventricular ectopic beats. In addition, 11.2% of patients had atrioventricular block (incomplete/partial), 8.8% had atrial fibrillation, and 14.7% had painless ischemia of 1 to 3 episodes per day. Depending on the mean heart rate (HR) according to HM, patients with chronic glomerulonephritis were divided into two subgroups. Subgroup A included 38 patients with heart rate less than or equal to 70 beats/min, subgroup B — 131 patients with heart rate of more than 70 beats/min. With equal values of uric acid, total CL, HDL-C, TG, plasma creatinine and blood fibrinogen in subgroup B there was a significant increase in LDL-C concentration (3.58 (2.74; 5.54) mmol/l vs. 2.82 (2.30; 3.86) mmol/l; p<0.05) and a decrease in the estimated GFR (70.4 (48.8; 96.3) ml/min vs. 85.7 (31.5; 103,1) ml/min; p<0.05), in comparison with subgroup A. In subgroup B a tendency to increase the degree of daily urine excretion of protein was observed. The data obtained confirm the fact that HM with the analysis of heart rate is of significant clinical importance for the diagnosis of cardiovascular disorders and the prevention of cardiovascular complications in patients with chronic glomerulonephritis at the predialysis stage of the disease.

THE CLINICAL SIGNIFICANCE OF THE DAILY MONITORING OF HOLTER ECG IN CHRONIC GLOMERULONEPHRITIS AT THE PREDIALYSIS STAGE OF THE DISEASE