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The objective of the study was to analyze the clinical signs of chemotherapy-induced neuropathy (CIPN) in cancer patients and explore pharmacotherapy correction options using vitamin B supplements. Materials and methods. During the first stage that lasted from May to September 2017 after the screening period, 219 patients (mean age of (50.4 ± 6.9) years) were selected for the study; 105 (46.7%) of them were female patients undergoing chemotherapy treatment cycles at Samara Regional Oncological Clinic. The methods of standard neurological examination and patient questioning established clinical signs of polyneuropathy: its localization, the main manifestations, including sensory and/or pain disorders. The patients were further randomized into two groups: group 1 received vitamin B supplements, and group 2 received no vitamin B supplements. The patients were observed for 60 days. Results. The incidence of polyneuropathy in oncology patients receiving chemotherapy turns out to be very high. The phenotype of clinical signs and their severity and localization is probably related to the type of the drug agent used. Our study demonstrated the effectiveness of the use of step-by-step therapy with group B supplements in order to reduce the clinical manifestations of polyneuropathy.

CLINICAL SIGNS OF CHEMOTHERAPY-INDUCED NEUROPATHY IN CANCER PATIENTS AND PHARMACOTHERAPY CORRECTION OPTIONS