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The objective of the study: To estimate a possibility of use of zinc and its fractions levels as the indicator reflecting a condition of antioxidant system at patients with COPD or in groups of high risk. Materials and methods. Patients with COPD, smokers and non-smoking healthy people participated in a study. Spirometry was carried out for all study subjects. Forced expiratory volume1 (FEV1) was determined followed by calculation of % FEV1 from the normal value. Taking into account the importance of an oxidative stress in COPD pathogenesis, the level of activity of the main enzyme of antioxidant defense — superoxide dismutase, levels of zinc and its fractions as main component of the enzyme and also albumin level as main metabolically active zinc transporter were determined. The indicator “proportion of bound zinc fraction” was introduced to define zinc fractions changes. The results of the study. It is defined that at smokers with minimal impairment of the respiratory function the change of indicators are similar to that at patients with diagnosed COPD. Statistically significant differences in the level of the studied indicators at non-smoking patients are also revealed. A Spearman correlation analysis showed significant correlation between % FEV1 from normal value and SOD activity; between SOD activity and total and bound zinc levels. This confirms a hypothesis of the possibility to use zinc and its fractions levels in screening examinations as a parameter that reflects the state of antioxidant system in smokers.

LEVEL OF ZINC AND ITS FRACTIONS AS REFLECTION OF A CONDITION OF ANTIOXIDANT SYSTEM AT THE CHRONIC OBSTRUCTIVE LUNG DISEASE