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Leaves extract of Senna alata L. are used as indigenous medicine to treat various types of disease like ulcers, stomach, pain and fever. The present study was undertaken to study the phytochemical screening, total phenolic compounds (TPC), total flavonoid compounds (TFC) and in vitro antioxidant of Senna alata leaves’ extract growing in Ngaoundéré town (Cameroon). Respective bioactivities of the phytochemicals were determined. Quantitative analysis of the total phenolic content was determined by using the Folin-Ciocalteu method while total flavonoid was estimated using aluminium trichloride (AlCl3). The antioxidant capacities in the forms of DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (Ferric Reducing Antioxidant Power) were evaluated by spectrophotometric methods. For these purposes, aqueous extract were prepared. Now the experimental screening of phytochemicals showed negative results for the absence of reducing compounds, steroids/triterpenes, and tannins. The results showed that TPC, TFC values were higher: 14.768±0.26 mg GAE per g of extract, 4.32±0.12 mg Ru per g of extract, respectively. The Senna alata Leaves’ extract (SALE) exhibited the best DPPH inhibition concentration 50% (IC50 = 12.05 mg. mL ), and FRAP method (IC50 = 2.79 mg. mL ) compared to that of the positive control, ascorbic acid (IC50 = 17.69 mg/mL); Hence, extract from the leaves of Senna alata contains high secondary metabolites which accounts for its strong antioxidant ability thus justifying its use as natural occurring antioxidants in folkloric medicine.

In Vitro Antioxidant Property and Phytochemical Constituents of Senna alata Leaves Aqueous Extract Collected in Ngaoundéré (Cameroon)