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Periodontal diseases is a world wide prevalent chronic infection, which is caused by accumulation of specific microorganism or group of microorganisms in dental plaque, which results in the progressive loss of bone around teeth leading to loss of teeth. The present study was developed and evaluated in situ gelling system of Lomefloxacin hydrochloride by using different concentrations of Carbopol 934 for treatment of periodontitis. The drugpolymer compatibility were study using DSC. The seven formulation (L1 to L7) were prepared and their appearance, pH, viscosity, gelling capacity, %drug content, syringeability and in vitro drug release were investigated. The findings of compatibility study indicates that the drug was compatible with polymer. The developed formulations showed satisfactory results for pH, viscosity, gelling capacity, %drug content, syringeability and in vitro drug release. Based on maximum desirability and cost effectiveness formulation L7 with 1.0 % of polymer Carbopol 940, showed a sustained release of drug for 16 hrs.

Formulation and Evaluation Sustained Release of Lomefloxacin Hydrochloride from In-Situ Gel for Treatment of Periodontal Diseases