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Flucytosine is a semisynthetic macrolide antibiotic used for the treatment of trachoma caused by Chlamydia trachomatis, a gram negative bacteria. The study was planned to formulate in situ ocular gel of Flucytosine to prolong the pre-corneal residence time and gives the better bioavailability as compare to conventional dosage form. The in situ gel of Flucytosine was prepared by mixing with polymer of xanthan gum, HPMC and sodium alginate in different ratio. The six different formulations were prepared and evaluated for Clarity, visual appearance, pH, gelling capacity, drug content, in vitro drug release, kinetic model and ocular irritancy. The best formulation was subjected for stability study. The results of evaluation parameters were satisfactorily for all formulations, while F4 demonstrated maximum drug release at 8 hr and follow zero order drug release. The findings of ocular irritant indicates the F4 were non irritant and safe to use. The outcomes of stability study indicate that the F4 gel stored at room temperature and accelerated temperature were found to be comparatively stable. The study concluded that the in situ ocular gel of Flucytosine will be substitute for conventional eye drops in future.

Design and Characterization of Flucytosine Loaded Bioadhesive In Situ Ophthalmic Gel for Improved Bioavailability