Formulation Development and In-vitro Evaluation of Mouth Dissolving Tablets of Celecoxib Employing Distinctive Proportion of Disintegrating Agents

In present study we planned to formulate and evaluate mouth dissolving tablets of Celecoxib using superdisintegrants agents namely Crospovidone and Sodium starch glycolate in various ratios. The mouth dissolving tablets were prepared by direct compression method using Crospovidone and Sodium starch glycolate. Tablets blends were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like thickness, friability, hardness, weight variation, wetting time, water absorption ratio and disintegration test by using standard procedures. The results of all these tests were found to be satisfactory. The in-vitro dissolution study was carried out for 14 min using paddle method in phosphate buffer (pH 6.8) as dissolution media. The data of in-vitro dissolution of tablets revealed that 76 to 100% of drug release from various formulations at 14 min. The formulation C7 exhibited better results as compared to other formulations.