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Background:Post-extraction   alveolar bone height and width never reach the same dimensions as before   extraction. A   combination of propolis extracts and bovine bone graft (BBG) that are anti-inflammatory, antioxidant, osteoinductive and osteconductive   is   expected to improve bone regeneration.  Purpose:  Knowing the effect of the combination of propolis extracts and BBG on the number of osteoclast and osteoblast as an effort to preserve the socket after extraction of Cavia cobaya teeth.  Methods:  56 Cavia cobaya was divided into   eight   groups  :   the lower left incisor was extracted,   and   the socket was filled with 2% poly ethylene glycol (PEG), propolis extract+PEG, BBG+PEG, and a combination of propolis extract+BBG+PEG. The incisors socket of animals models were executed on the 14 th  and 30 th  days. Using HE   for histopathological   examination, the number of osteoclasts and osteoblasts were counted with a 400x magnification light microscope with   nine   visual fields. The data were   analysed via   one-way ANOVA and Tukey HSD tests.  Results:  The highest mean number of osteoclasts occurred in the BBG+PEG 14 th  day group and the lowest occurred in the propolis extract+BBG+PEG 14 th  day group. The highest mean number of osteoblasts occurred in the propolis + BBG + PEG combination 30 th  day group, the lowest occurred in the control group (PEG) on the 14 th  day.  Conclusion:  The 2% combination of propolis extracts and BBG effectively reduces the osteoclast number and increases the osteoblast number in preserving   the   socket after extracting Cavia cobaya teeth.

dental journal

The effect of propolis extract and bovine bone graft combination on the number of osteoclast and osteoblast as an effort to preserve post-extraction socket (on Cavia cobaya)