English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background:    Periodontitis is a chronic infectious disease affecting the global population. In Indonesia, the prevalence of periodontal    disease has reached 57.6% across all age groups. The bacterium considered as the orginator factor of periodontitis is Porphyromonas    gingivalis (P. gingivalis). Herbal ingredients are currently being promoted as a form of treatment because of the minimal side effects    they induce. Andrographis paniculata Nees (ApN) extract produces pharmacological effects, including ones immunomodulatory in    character, rendering possible its application as a preparation for treating periodontitis.    Purpose:    The purpose of the study was to    prove the potency of Andrographis paniculata Nees extract in increasing the viability of monocytes following exposure to P. gingivalis.    Methods:    The sample was divided into four groups, namely; Control negative (C-): monocytes in the medium, not exposed to P.    gingivalis; Control positive (C+): monocytes in the medium, exposed to P. gingivalis; Treatment I (AP25): monocytes with 25% ApN    extract, exposed to P. gingivalis; Treatment II (AP50): monocytes with 50% ApN extract, exposed with P. gingivalis. The monocytes were    exposed to 100 uL P. gingivalis for 4.5 hours and stained with trypan blue. Observations were conducted using an inverted microscope    at 200x magnification. The percentage of viable monocytes was calculated based on the ratio of the number of the cells which absorbed    trypan blue staining to that which did not. Data was tested using a one-way ANOVA followed by an LSD test.    Results:    There were    significant differences between the treatment groups in the number of viable monocytes (p=0.001) they contained. Monocyte viability    was higher in the 25% ApN extract group than that exposed to 50% P. gingivalis.    Conclusion:    Andrographis paniculata Nees extract    demonstrates the potency to increase monocyte viability following exposure to P. gingivalis.

The potency of Andrographis paniculata Nees extract to increase the viability of monocytes following exposure to Porphyromonas gingivalis