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Currently, infectious disease is increase in world wide. The African leaf (Vernonia amygdalina) – VA is used to antimicrobial treatment. It may protect the host against microbial attack in several ways. This plant has attracted the interest of researchers in recent decades because of the constituents have important roles in modulating immune system in bacteria infection. The aim of study is to analyze the prophylactic activity of V A’s ethanol extract in modulat ing the levels of IL-6 and IL-10 as well as the number of bacteria in male W istar rats that were (Staphylococcus aureus) – SA – infected. The re were as many as 30 rats were divided into 5 treatment groups: negative control (NC) was treated by CMC Na 2% (w/v) ; positive control (PC) was treated by 9mg/200g body weight (BW) of cephadroxil ; T1 ; T2 ; and T3 were respectively treated with ethanol extract of V A of doses 20mg/200g BW; 40mg/200g BW and 80mg/200g BW. After the oral treatment was administered, all the rats were in f ected with 0.25mL (3x10 8 cfu) SA via intra peritoneal route. Their blood was draw n in order to identify the IL-6 and IL-10 levels by ELISA . Furthermore, their peritoneal fluid was also taken to count the number of survived bacteria by pour plate method. The results are showed median of IL-6 and IL-10 levels as well as bacterial number respectively in NC 370.530pg/mL; 67.044pg/mL; 7.4x10 3 cfu/mL; in PC 234.556pg/mL; 42.839pg/mL; 6.8x10 3 cfu/mL,; in T1 164.019pg/mL; 17.240pg/mL; 1.1x10 4 cfu/mL; in T2 49.291pg/mL; 2.961 pg/mL; 6.3x10 3 cfu/mL and in T3 43.342pg/mL; 13.235pg/mL; 7.1x10 3 cfu/mL. T hese results are implied that V A’s ethanol extract is effect ive as a prophylactic agent to suppress the bacterial invasion at dose of 40mg/200g BW in Wistar rat particularly shown by the decrease level of IL-6 and the number of bacteria.

EFFECT OF AFRICAN LEAF (VERNONIA AMYGDALINA) TO IL-6 AND IL-10 LEVEL ON STAPHYLOCOCCUC AUREUS INFECTION