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Background: Peritumoral clefts are noticed in carcinomas of many organs, and were thought to be artifacts due to fi xation and preparation of slides. Today they are considered to be additional marker of malignancy and the refl ection of epithelial-stromal interaction. The hypothesis was that peritumoral clefts in breast carcinoma refl ect changes in stromal composition and characteristics, and are related to lymphangiogenesis in tumor tissue. Materials and methods: One hunderd (59% with axillary lymph nodes metastases) invasive ductal breast carcinomas of no special type were analyzed for the presence and abundance of peritumoral clefts and immunohistochemically for CD34, vimentin, smooth muscle actin (SMA) and D2-40 (podoplanin) in tumor stroma. Results: Peritumoral clefts were found in 92% of invasive carcinomatous tissue and were absent in surrounding healthy tissue and around ducts of in situ component (with 5% do 100%. The threshold of 30% of peritumoral clefts was determined by receiver operating characteristic (ROC) analysis. The density of small lymphatic vessels in the stroma of the tumor, and outside the tumor tissue did not show signifi cant correlation with the threshold value. In patients with axillary metastases, peritumoral lymphovascular invasion (LVI) was found twice and intratumoral LVI fi ve times more often than in patients without axillary metastases. Neither peritumoral nor intratumoral LVI were signifi cantly correlated with the threshold value of 30%. In patients with axillary lymph node metasases, peritumoral lymphovascular invasion (LVI) was found twice as often, and intratumoral LVI 5 times as often than in patients without axillary lymph node metastases. Conclusion: Peritumoral clefts in invasive breast carcinoma refl ect stromal changes of fi broblasts and are not associated with lymphangiogenesis, that is probably caused by some other pathogenesis.

Gustoća limfnih i malih krvnih žila u stromi tumora i peritumoralnog tkiva u invazivnom karcinomu dojke bez posebnih obilježja