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Objective: To evaluate preoperative predictive factor for biochemical recurrence (BCR) after radical prostatectomy (RP) for high risk prostate cancer (PCa). Methods: We retrospectively evaluated 96 patients with clinically localized or minimally invasive high risk PCa who underwent RP. High risk PCa was defined by D’Amico’s criteria prostate-specific antigen (PSA)> 20 ng/ml or clinical T2c/3 or a biopsy Gleason Score ≥ 8.The log-rank test and Cox proportional hazards analysis were used to evaluate predictive factors. Results: The follow-up periods ranged from 1-111 months (median 43.1 months). Twenty-four of 96 (25%) patients had BCR after RP but only one patient (1%) died of cancer during the follow -up period. The five-year BCR-free survival rate was 68.4% for all patients. A preoperative serum PSA level of more than 20 ng/ml was a risk factor for BCR (p=0.008, HR3.632 95%CI 1.402-9.409, Cox proportional hazards analysis) and patients having multiple risk factors had a higher risk for BCR than patients with a single risk factor (p=0.003, log-rank test). Conclusion: A serum PSA level of more than 20 ng/ml is a risk factor for BCR in high risk PCa after RP. Patients having multiple risk factors have a high risk for BCR.

arc journal of urology

Preoperative Serum Prostate-Specific Antigen Level is a Predictive Factor for Biochemical Recurrence in High Risk Prostate Cancer after Radical Prostatectomy