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The adverse health effects caused by chronic arsenic exposure of natural origin have been a major global health concern. A large number of people (approx. 150 million) have been suffering from various arsenic related diseases all over the world [1]. Prolonged chronic exposure to arsenic causes multi-organ diseases like skin lesions (melanosis, keratosis and Bowen’s disease), gastrointestinal diseases, cardiovascular and respiratory diseases, and neurological, haematological and hepatic disorders, diseases of kidney, liver, and cancers, mainly of skin, lung and urinary bladder [2 6]. More than 6 million people in West Bengal, India are exposed to arsenic contaminated drinking water (above the National permissible limit of 50 μg/L). Alarmingly, an estimated population of more than 0.3 million has been reported to have skin lesions [7]. Skin lesions have been considered as a long-term biomarker of cumulative arsenic exposure and as a major diagnostic criterion in screening the affected population [8]. The typical arsenical skin Abstract

Urinary Porphyrin Profile as Early Biomarker vis-a-vis Malonaldehyde as Oxidative Stress Indicator in Arsenic Exposed Individuals, West Bengal, India