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Thus mutated fibromine would be unable, as a tumor suppressor, to control the maturation and proliferation of glial and neuronal cells, which explains the frequent development of neurological tumors (glioma, neuroma, and neurofibroma), which are the main signs of this disease [1-3]. Other clinical manifestations may be associated with these neurological tumors: cutaneous, bone, endocrine, cardiac, vascular, and ocular involvement signing the systemic nature of this disease and making its diagnosis sometimes a real challenge for the clinician [2,4].

Peripheral Facial Palsy in Adult Von Recklinghausen Neurofibromatosis