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Objectives: This study designed to treat iron deficiency anemia before labor using intravenous Iron Saccharate. Materials and Methods: One hundred and twenty-one (121) pregnant women, with hemoglobin level between 8-10 gm/dl due to iron deficiency anemia, who cannot tolerate oral iron preparations included in this comparative prospective study, and treated with intravenous Iron Saccharate infusion for correction of iron deficiency anemia before labor. Treatment efficacy checked by comparing pre-medication values of; hemoglobin, reticulocytes, serum ferritin, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) by the 60 days’ post-medication values. Results: The mean premedication hemoglobin significantly increased from 8.7 ± 2.66 to 11.8 ± 2.02 gm/dl 60 days’ after Iron Saccharate infusion (P=0.001 (95% CI; -3.71, -3.1, -2.48)), and the mean premedication ferritin level significantly increased from 10.7 ± 5.1 to 123.5 ± 3.9 ug/l 60 days’ after Iron Saccharate infusion (P=0.002 (95% CI; -113.9, -112.8, -111.6)). In addition; the mean premedication RBCs MCV significantly increased from 73.2 ± 6.1 to 93.5 ± 4.7 FL 60 days’ after Iron Saccharate infusion (P=0.002 (95% CI; -21.70, -20.3, -18.8)), and the mean premedication RBCs MCH significantly increased from 24.6 ± 8.1 to 25.9 ± 5.7 pg 60 days’ after Iron Saccharate infusion (P=0.0001 (95% CI; -3.1, -1.3, 0.51)). While, the mean premedication reticulocytes count significantly decreased from 3.6 ± 4.2 to 0.9 ± 3.3 106/mm3 60 days’ after Iron Saccharate infusion (P=0.005 (95% CI; 1.72, 2.7, 3.67)). Conclusion: Iron Saccharate infusion is an effective option for correction of iron deficiency before labor in women who cannot tolerate oral iron preparations; it increases the hemoglobin, replaces the depleted iron store, and reduces the need for blood transfusion.

Intravenous Iron Saccharate Infusion for Treatment of Iron Deficiency Anemia before Labor